RAD-140 vs. RAD-150: A Research Comparison of Two SARMs
- Biotech Labs Co.
- Aug 4, 2025
- 3 min read
RAD-140 (Testolone) and RAD-150 (TLB-150 Benzoate) are selective androgen receptor modulators (SARMs) that have become popular topics in the research community for their potential influence on muscle tissue development, bone density, and anabolic pathways.
Although they are similar in many ways, RAD-150 is a benzoate esterified version of RAD-140, which gives it unique properties in research applications.
At Biotech Labs Co., we supply both RAD-140 and RAD-150 for laboratory research use only — they are not approved for human or veterinary use.
What Is RAD-140?
RAD-140 is a nonsteroidal SARM designed to selectively bind to androgen receptors in muscle and bone tissue. Research models suggest that RAD-140 may mimic some anabolic effects of testosterone without converting to estrogen or significantly affecting other hormonal pathways.
Key points in research:
High binding affinity to androgen receptors
Strong anabolic-to-androgenic activity ratio
Investigated for lean muscle preservation in animal studies
What Is RAD-150?
RAD-150 is essentially RAD-140 with a benzoate ester attachment. In organic chemistry, esterification can change a compound’s absorption rate, half-life, and stability.
In research contexts, this structural change may:
Prolong the compound’s activity in vivo
Alter metabolic breakdown rate
Provide more sustained receptor binding
Structural Difference Between RAD-140 and RAD-150
Property RAD-140 RAD-150 (TLB-150 Benzoate)
Chemical Structure Base SARM Esterified with benzoate group
Half-Life (Studies) ~24 hours Reported to be longer (unverified)
Release Rate Faster onset Slower, sustained release
Research Use Focus Muscle growth, neuroprotection Sustained anabolic research models
Stability Stable in base form Potentially more stable in solution
Mechanism of Action (In Research)
Both RAD-140 and RAD-150 act as selective androgen receptor modulators, meaning they target androgen receptors in muscle and bone tissue while showing minimal interaction with receptors in other organs.
In lab studies:
Binding to androgen receptors initiates anabolic signaling
May increase protein synthesis
May reduce muscle wasting in experimental models
RAD-150’s ester group may delay the breakdown of the active compound, leading to a longer action window in research scenarios.
Research Applications & Observations
⚠️ Note: The following applications are based on preclinical studies and are for educational purposes only. Neither compound is approved for human or veterinary use.
1. Muscle Tissue Research
Both RAD-140 and RAD-150 are studied for their anabolic potential in maintaining or increasing lean muscle mass in test subjects.
2. Bone Density Studies
SARMs like RAD-140 and RAD-150 have been investigated for their role in stimulating bone mineralization in aging-related models.
3. Neuroprotective Models
RAD-140 has been studied for potential neuroprotective effects in animal research; it is unknown if RAD-150 shares these properties.
4. Metabolic and Endurance Research
Some studies have explored SARMs for potential metabolic benefits, though data is still limited.
RAD-140 vs RAD-150 in Research: Key Takeaways
Similarity: Both target androgen receptors selectively for anabolic research.
Difference: RAD-150 is esterified for potential longer-lasting activity.
Potential Use Case: RAD-140 may be more suited for shorter-term or more frequent administration studies; RAD-150 may be used for sustained-release research models.
Research Dosing Reference (Educational Only)
RAD-140:
Preclinical research has used dosages from 5mg to 30mg per day in animal models.
Less published data is available, but dosing is often referenced in similar ranges to RAD-140, with adjustments for potential ester effects.
⚠️ Disclaimer: All dosing references are from third-party research sources and are provided for educational purposes only.
Storage & Handling Guidelines
Store in a cool, dry place, away from direct light
Keep containers sealed to avoid contamination
Follow your institution’s research safety protocols
Legal Disclaimer
RAD-140 and RAD-150 sold by Biotech Labs Co. are intended for laboratory research use only. They are not approved for human or veterinary consumption. All references to biological effects or dosing are from third-party research and are provided for educational purposes only.
Final Thoughts
While RAD-140 and RAD-150 share similar research targets, their chemical differences may influence their absorption rate, stability, and potential duration of action in laboratory settings. For researchers looking to explore anabolic pathways and androgen receptor interactions, both SARMs offer unique opportunities for investigation.
For high-quality, lab-tested SARMs, trust Biotech Labs Co. as your reliable source.
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